Complex Biological Systems
A comprehensive track within the Integrative Program in Quantitative Biology for training students in the understanding and engineering of complex biological systems from the molecular and cellular levels to the whole organism. To meet the vast challenges ahead, the Complex Biological Systems track proposes to depart significantly from a traditional curriculum. Students within this track will develop novel approaches to solve the critical sociology and language problems associated with training scientists to be simultaneously conversant in the languages of biology, mathematics, physics and engineering. UCSF has overseen the recruitment of 10 new faculty to expand expertise in critical quantitative areas and built an entirely new curriculum focused on the observation, modeling, manipulation and design of complex biological systems.
Students wishing to pursue this track are admitted into either the Biophysics or Bioinformatics graduate programs. A PhD is awarded by the respective program with an emphasis on research in systems biology.
Image
Heterotrimeric G protein (Protein Data Bank entry 1gg2) with the alpha subunit shown in green, the beta subunit in light blue, and the gamma subunit in brown.
Image
The structure of the yeast ribosome determined by a combination of cryo- electron microscopy and comparative protein structure modeling. C. Spahn, R. Beckmann, N. Eswar, P. Penczek, A. Sali, G. Blobel, J. Frank. Cell 107, 361-372, 2001.
Image
A crystal packing of the Thermus thermophilus chaperonin complex from Protein Data Bank entries 1we3 and 1wf. Structure (Camb). 2004 Aug;12(8):1471-80.
Image
0.82A resolution crystal structure of alpha-lytic protease at pH 5. Protein Database Entry
Image
Semliki forest virus. The bowl of smoke is a 9 angstrom resolution density map from electron cryo-microscopy. Mol Cell. 2000 Feb;5(2):255-66.
Image
Osherovich, L. Z., Weissman, J. S., (2001). Multiple Gln/Asn-Rich prion domains confer susceptibility to induction of the yeast [PSI+] prion. Cell: 106(2):183-194
Image
Powers RA, Morandi F, Shoichet BK. Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase. Structure 10, 1013-1023, 2002.
Image
Actin Q-dot fluorescence image from the Mullins Lab.
Image
A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic 7 903-916 (2006)
